Slow energy relaxation of macromolecules and nano-clusters in solution

Many systems in the realm of nanophysics from both the living and inorganic world display slow relaxation kinetics of energy fluctuations. In this paper we propose a general explanation for such phenomenon, based on the effects of interactions with the solvent. Within a simple harmonic model of the system fluctuations, we demonstrate that the inhomogeneity of coupling to the solvent of the bulk and surface atoms suffices to generate a complex spectrum of decay rates. We show for Myoglobin and for a metal nano-cluster that the result is a complex, non-exponential relaxation dynamics.Comment: 5 pages, 3 figure

A Beam Driven Plasma-Wakefield Linear Collider: From Higgs Factory to Multi-TeV

Plasma wakefield acceleration (PWFA) holds much promise for advancing the energy frontier because it can potentially provide a 1000-fold or more increase in acceleration gradient with excellent power efficiency in respect with standard technologies. Most of the advances in beam-driven plasma wakefield acceleration were obtained by a UCLA/USC/SLAC collaboration working at the SLAC FFTB[ ]. These experiments have shown that plasmas can accelerate and focus both electron and positron high energy beams, and an accelerating gradient in excess of 50 GeV/m can be sustained in an 85 cm-long plasma. The FFTB experiments were essentially proof-of-principle experiments that showed the great potential of plasma accelerators. The FACET[ ] test facility at SLAC will in the period 2012-2016 further study several issues that are directly related to the applicability of PWFA to a high-energy collider, in particular two-beam acceleration where the witness beam experiences high beam loading (required for high efficiency), small energy spread and small emittance dilution (required to achieve luminosity). The PWFA-LC concept presented in this document is an attempt to find the best design that takes advantage of the PWFA, identify the critical parameters to be achieved and eventually the necessary R&D to address their feasibility. It best benefits from the extensive R&D that has been performed for conventional rf linear colliders during the last twenty years, especially ILC[ ] and CLIC[ ], with a potential for a comparably lower power consumption and cost.Comment: Submitted to the proceedings of the Snowmass Process CSS2013. Work supported in part by the U.S. Department of Energy under contract number DE-AC02-76SF0051

Finding instabilities in the community structure of complex networks

The problem of finding clusters in complex networks has been extensively studied by mathematicians, computer scientists and, more recently, by physicists. Many of the existing algorithms partition a network into clear clusters, without overlap. We here introduce a method to identify the nodes lying ``between clusters'' and that allows for a general measure of the stability of the clusters. This is done by adding noise over the weights of the edges of the network. Our method can in principle be applied with any clustering algorithm, provided that it works on weighted networks. We present several applications on real-world networks using the Markov Clustering Algorithm (MCL).Comment: 4 pages, 5 figure

Warm and Cold Denaturation in the Phase Diagram of a Protein Lattice Model

Studying the properties of the solvent around proteins, we propose a much more sophisticated model of solvation than temperature-independent pairwise interactions between monomers, as is used commonly in lattice representations. We applied our model of solvation to a 16-monomer chain constrained on a two-dimensional lattice. We compute a phase diagram function of the temperature and a solvent parameter which is related to the pH of the solution. It exhibits a native state in which the chain coalesces into a unique compact conformation as well as a denatured state. Under certain solvation conditions, both warm and cold denaturations occur between the native and the denatured states. A good agreement is found with the data obtained from calorimetric experiments, thereby validating the proposed model.Comment: 7 pages, 2 figure